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No certain dose adjustment suggested when tofacitinib coadministered with potent CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with equally moderate CYP3A4 and strong CYP2C19 inhibitors .crizotinib boosts levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction could be needed
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